KRAS inhibitor-18

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KRAS inhibitor-18

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2230873-66-0

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

KRAS inhibitor-18 (compound 3-10) 是一种有效的KRAS G12C抑制剂，IC₅₀为 4.74 μM。KRAS inhibitor-18 在 MIA PaCA-2，A549 细胞中显示出 p-ERK 抑制活性，IC₅₀s 分别为 66.4，11.1 μM。KRAS inhibitor-18 具有研究胰腺癌，结直肠癌和肺癌的潜力。

生物活性

KRAS inhibitor-18 (compound 3-10) is a potentKRAS G12Cinhibitor with anIC₅₀of 4.74 μM. KRAS inhibitor-18 shows p-ERK inhibition activities with IC₅₀s of 66.4, 11.1 μM in MIA PaCA-2, A549 cells, respectively. KRAS inhibitor-18 has the potential for the research of pancreatic, colorectal, and lung cancers^[1].

IC₅₀& Target^[1]

KRas G12C

4.74 μM (IC₅₀)

分子量

453.87

Formula

C₂₀H₁₅ClF₃N₃O₂S

CAS 号

2230873-66-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.