KRAS inhibitor-12

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KRAS inhibitor-12

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2230874-00-5

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

KRAS inhibitor-12 (compound 6-1) 是一种有效的KRAS G12C抑制剂，IC₅₀为 0.537 μM。KRAS inhibitor-12 在 MIA PaCA-2，A549 细胞中显示出 p-ERK 抑制活性，IC₅₀s 分别为 1.3，3.7 μM。 KRAS inhibitor-12 具有研究胰腺癌，结直肠癌和肺癌的潜力。

生物活性

KRAS inhibitor-12 (compound 6-1) is a potentKRAS G12Cinhibitor with anIC₅₀of 0.537 μM. KRAS inhibitor-12 shows p-ERK inhibition activities with IC₅₀s of 1.3, 3.7 μM in MIA PaCA-2, A549 cells, respectively. KRAS inhibitor-12 has the potential for the research of pancreatic, colorectal, and lung cancers^[1].

IC₅₀& Target^[1]

KRas G12C

0.537 μM (IC₅₀)

分子量

452.33

Formula

C₁₉H₁₆Cl₂FN₅OS

CAS 号

2230874-00-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.