KRAS inhibitor-20

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KRAS inhibitor-20

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2411786-32-6

包装与价格：

产品介绍

KRAS inhibitor-20 是一种KRas^G12C致癌突变体的小分子抑制剂。KRAS inhibitor-20 抑制KRas^G12C的 IC₅₀<10 nM。

生物活性

KRAS inhibitor-20 is a small molecular inhibitor ofKRas^G12C, the oncogenic mutant. KRAS inhibitor-20 inhibitsKRas^G12Cwith the IC50 value<10 nm^[1].

IC₅₀& Target^[1]

KRAS(G12C)

<10 nM (IC₅₀,^[1])

体外研究
(In Vitro)

KRAS inhibitor-20 (compound 12b) resultsKRas^G12Calkylation human lung cancer adenocarcinoma (HCC 1171) with an EC₅₀value of 3.3 nM^[1].

分子量

604.68

Formula

C₃₁H₄₀F₄N₆O₂

CAS 号

2411786-32-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.