GB83

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GB83

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1252806-86-2

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

GB83 是一种有效的 PAR2 拮抗剂。GB83 逆转中性粒细胞弹性蛋白酶诱导的滑膜炎和疼痛。GB83 阻断 MET-1 上清液对 NG 神经元的影响。

生物活性

GB83 is a potentPAR2antagonist. GB83 reverses neutrophil elastase‐induced synovitis and pain. GB83 blocks the effect of MET-1 supernatant on NG neurons^[1].

IC₅₀& Target^[1]

PAR2

体外研究
(In Vitro)

GB83 (10 μM) blocks the effect of MET-1 (microbial ecosystem therapeutic-1) supernatant on nodose ganglion (NG) neurons^[2].

体内研究
(In Vivo)

GB83 (5 μg; i.p.) reverses neutrophil elastase‐induced synovitis and pain in PAR2 KO mice^[1].

Animal Model:	8-14 weeks, 20-30 g male C57Bl/6 mice (PAR2 KO mice)^[1]
Dosage:	5 μg
Administration:	I.p.; 3 times at 10 min before and 110 and 230 min after neutrophil elastase administered
Result:	Significantly blocked the neutrophil elastase induced increase in vascular perfusion, as well as the number of rolling adherent leukocytes, and also significantly attenuated hindpaw allodynia.

分子量

548.72

Formula

C₃₂H₄₄N₄O₄

CAS 号

1252806-86-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.