2-Methylthio-AMP (2-MeSAMP) diTEA is a selective and directP2Y₁₂antagonist. 2-Methylthio-AMP diTEA is an inhibitor of ADP-dependent platelet aggregation^[1][2][3].

2-Methylthio-AMP (2-MeSAMP) diTEA inhibits agonist-mediated α_IIbβ₃activation in platelets^[1].
2-methylthio-AMP (50 μM; for 5 minutes) diTEA does not significantly inhibit thrombin, PAR1-AP, PAR4-AP, or ADP-mediated platelet Ca²⁺mobilization. 2-methylthio-AMP diTEA fails to inhibit Ca²⁺mobilization in P2Y₁₂-deficient mouse platelets and does not raise cAMP or induce vasodilator-stimulated phosphoprotein phosphorylation in wild-type platelets^[1].

595.69

Solid

C₂₃H₄₆N₇O₇PS

1227193-98-7

Room temperature in continental US; may vary elsewhere.

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)