PSB-1114 tetrasodium is a potent, enzymatically stable, and subtype-selectiveP2Y₂receptoragonist with anEC₅₀of 134 nM. PSB-1114 tetrasodium displays >50-fold selectivity versus the P2Y₄(EC₅₀of 9.3 μM) and P2Y₆(EC₅₀of 7.0 μM) receptors^[1].

EC50: 134 nM (P2Y₂receptor), 9.3 μM (P2Y₄receptor); 7.0 μM (P2Y₆receptor)^[1]

PSB-1114 (4-Thio-β,γ-difluoromethylene-UTP; compound 14g) displays >60-fold selectivity versus P2Y4 and P2Y6 receptors. Because of its high potency, selectivity, and expected metabolic stability toward ectonucleotidases, in particular NTPDases, PSB-1114 may be a useful pharmacological tool for studying P2Y2 receptors^[1].

622.14

C₁₀H₁₁F₂N₂Na₄O₁₃P₃S

1657025-60-9

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.