Talnetant (SB 223412) hydrochloride is a selective, competitive, brain-permeableNK3receptor antagonist with aK_iof 1.4 nM in hNK-3-CHO cells. Talnetant hydrochloride is 100-fold more selective for hNK-3 relative to the hNK-2 receptor and has no affinity for hNK-1. Talnetant hydrochloride can be used in schizophrenia-related studies^[1][2][3].

Talnetant (SB 223412) (0.1-1 μM) hydrochloride can reduce the accumulation of NKB-induced IP in U-2OS cells expressing the human NK3 receptor^[3].

Talnetant (SB 223412) hydrochloride (0.5-2 mg/kg iv, 2min pretreatment) can inhibit the miosis induced by senktide (25μg, iv) in a dose-dependent manner with an ED₅₀of 0.44mg/kg in conscious rabbits^[1].
Talnetant (SB 223412) hydrochloride (i.p., 1-100 mg/kg, 1 h) can significantly attenuate senktide-induced "wet dog wagging" behavior in a dose-dependent manner, significantly increase extracellular dopamine and norepinephrine in the medial prefrontal cortex and reduce haloperidol-induced increases in dopamine levels in the vomeronasal nucleus of freely moving guinea pigs^[3].

418.92

C₂₅H₂₃ClN₂O₂

204519-66-4

盐酸他奈坦

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Please store the product under the recommended conditions in the Certificate of Analysis.