| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| 生物活性 | Men 10376 TFA is a selectivetachykinin NK-2 receptorantagonist, with aKiof 4.4 μM for rat small intestine NK-2 receptor[1]. | ||||||||||||||||
| IC50& Target | Ki: 4.4 μM (NK-2 receptor, rat small intestine)[1] | ||||||||||||||||
| 体外研究 (In Vitro) | Men 10376 is a selective tachykinin NK-2 receptor, with a Kiof 4.4 μM, and shows low selectivity for NK-1 and NK-3 receptors (Ki, >10 μM)[1]. Men 10376 shows pA2s of 5.66 and 8.08 for NK-1 (guinea-pig ileum) and NK-2 receptors (endothelium-deprived rabbit pulmonary artery). Men 10376 shows no effect on NK-3 receptor (Ki, >10 μM)[2]. | ||||||||||||||||
| 体内研究 (In Vivo) | Men 10376 (1 and 3 μmol/kg) antagonizes increase in bladder motility produced by the NK-2 receptor agonist in rats[2]. | ||||||||||||||||
| 分子量 | 1195.25 | ||||||||||||||||
| 性状 | Solid | ||||||||||||||||
| Formula | C59H69F3N12O12 | ||||||||||||||||
| Sequence | Asp-Tyr-{d-Trp}-Val-{d-Trp}-{d-Trp}-Lys-NH2 | ||||||||||||||||
| Sequence Shortening | DY-{d-Trp}-V-{d-Trp}{d-Trp}-K-NH2 | ||||||||||||||||
| 运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
| 储存方式 | Sealed storage, away from moisture and light
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) | ||||||||||||||||
| 溶解性数据 | In Vitro: H2O : 1.43 mg/mL(1.20 mM;Need ultrasonic) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
m.cnreagent.com