L-Cysteinesulfinic acid monohydrate is a potent agonist at several ratmetabotropic glutamate receptors(mGluRs) with pEC₅₀s of 3.92, 4.6, 3.9, 2.7, 4.0, and 3.94 formGluR1,mGluR5,mGluR2,mGluR4,mGluR6, andmGluR8, respectively^[1].

L-Cysteinesulfinic acid is an endogenous agonist of a metabotropic receptor coupled to stimulation of phospholipase D (PLD) activity. L-CSA is an endogenous agonist of the PLD-coupled metabotropic excitatory amino acids (EAA) receptor. L-CSA selectively activates the PLD-coupled receptor. 1 mM L-CSA induces a significant increase in PLD activity in hippocampal slices, whereas 1 mM concentrations of L-glutamate, L-aspartate, and L-HCA are without effect. L-CSA elicits a dose-dependent increase in PLD activity in rat hippocampal slices in the presence of iGluR antagonists, with an approximate EC₅₀of 500 uM. The PLD response induced by 1 mM L-CSA is not significantly decreased in the presence of 1 uM tetrodotoxin, suggesting that this response is not dependent upon L-CSA-induced increases in cell firing^[1].

171.17

Solid

C₃H₉NO₅S

207121-48-0

L-半胱氨酸亚磺酸一水合物

Room temperature in continental US; may vary elsewhere.

H₂O : 41.67 mg/mL(243.44 mM;Need ultrasonic)

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