Blarcamesine is an orally bioavailableSigma-1 receptoragonist andmuscarinic receptormodulator, with anticonvulsant, anti-amnesic, neuroprotective and antidepressant properties. Blarcamesine ameliorates neurologic impairments in a mouse model of Rett syndrome^[1].

Sigma-1 receptor, muscarinic receptor^[1]

Blarcamesine (10 mg/kg, 30 mg/kg; p.o.; daily; for 6.5 weeks) ameliorates motor deficits in Mecp2 HET mice with chronic administration^[1].
Blarcamesine ameliorates acoustic startle deficit in Mecp2 HET mice^[1].
Blarcamesine reverses deficits in visual acuity in older Mecp2 HET mice using the optokinetic response^[1].
Blarcamesine produces minimal effects on body weight gain in Mecp2 HET mice^[1].

281.39

C₁₉H₂₃NO

195615-83-9

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.