CYM50260 is a potent and exquisitely selectivesphingosine-1-phosphate 4 receptor (S1P₄-R)agonist with anEC₅₀of 45 nM. CYM50260 displays no activity against S1P₁-R, S1P₂-R, S1P₃-R and S1P₅-R^[1].

EC50: 45 nM (S1P₄-R)^[1]

CYM50260 (Compound 22aa) is a synthetic S1P4-R agonist. CYM50260 is found 3.5-fold more potent than the hit compound (HTS-hit)^[1].
CYM50260 suppresses the collagen-stimulated platelet aggregation, PDGF-AB secretion and sCD40L release. CYM50260 reduces the release of phosphorylated-HSP27 by collagen as well as the phosphorylation of HSP27^[2].

350.60

Solid

C₁₄H₁₁Cl₃FNO₂

1355026-60-6

Room temperature in continental US; may vary elsewhere.