Udifitimod

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Udifitimod

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1883345-06-9

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品名称

BMS-986166

产品介绍

Udifitimod (BMS-986166) 是一种有效的、选择性的和具有口服活性的S1P1R调节剂。Udifitimod 具有研究自身免疫性疾病的潜力。

生物活性

Udifitimod (BMS-986166) is a potent, selective and orally activeS1P1Rmodulator. Udifitimod has the potential for the research of autoimmune diseases^[1]^[2].

IC₅₀& Target^[1]

S1PR1

体内研究
(In Vivo)

Udifitimod (0.1, 0.5 mg/kg; p.o.; once daily for 21 days) 在自身免疫性脑脊髓炎模型中显示出抗炎活性^[1]。
Udifitimod (0.1, 0.5 mg/kg; p.o.; once daily for 50 days) 降低了胶原诱导性关节炎 (CIA) 模型的临床评分和足爪组织学评分^[1]。

Animal Model:	6-8 weeks, C57BL/6 female mice (autoimmune encephalomyelitis model (EAE))^[2]
Dosage:	0.1, 0.5 mg/kg
Administration:	P.o.; once daily for 21 days
Result:	Showed a dose-dependent reduction in clinical scores for inflammation.

Animal Model:	DBA/1 mice (collagen-induced arthritis (CIA) model)^[2]
Dosage:	0.1, 0.5 mg/kg
Administration:	P.o.; once daily for 50 days
Result:	Dose dependently reduced both the clinical score as well as the paw histology score following the dosing regimens.

分子量

379.54

Formula

C₂₅H₃₃NO₂

CAS 号

1883345-06-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.