Gly-Cyclopropane-Exatecan

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CAS NO:

2414254-49-0

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

Gly-Cyclopropane-Exatecan (compound 5c) 参与合成抗B7-H4抗体药物缀合物 (ADC)，含有 DNA 拓扑异构酶 I (Topoisomerase I) 抑制剂 Exatecan (HY-13631)。Gly-Cyclopropane-Exatecan 参与形成的 ADC 为 hu2F7-Exatecan (compound 34) 具有体内外抗肿瘤活性。

生物活性

Gly-Cyclopropane-Exatecan involves in the synthesis of anti-B7-H4ADC, containing Exatecan (HY-13631), a DNATopoisomeraseIinhibitor. Gly-Cyclopropane-Exatecan participated in the formation of the ADC hu2F7-Exatecan (compound 34), which showed antitumor activity in vivo and in vitro^[1].

IC₅₀& Target^[1]

Topoisomerase I

分子量

619.64

Formula

C₃₂H₃₄FN₅O₇

CAS 号

2414254-49-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.