LMP744

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LMP744

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

308246-52-8

包装与价格：

包装	价格(元)
1mg	电议
5mg	电议
10mg	电议
50mg	电议
100mg	电议

产品名称

MJ-III65
NSC706744

产品介绍

LMP744 (MJ-III65) 是一种 DNA 嵌合剂，是拓扑异构酶 1 (Top1)抑制剂，具有抗肿瘤活性。

生物活性

LMP744 (MJ-III65) is a DNA intercalator andTopoisomeraseI (Top1)inhibitor with antitumor activity^[1].

IC₅₀& Target

Top1

体外研究
(In Vitro)

The GI₅₀value of LMP744 (MJ-III-65) for NCI60 cells is 0.1 μM^[2].
LMP744 (0.1-5 μM, 3 days) induces dose-dependent accumulation of cells in the S and G₂phases of the cell cycle^[2].

Cell Viability Assay^[2]

Cell Line:	P388 and P388 Top1-deficient murine leukemia cells
Concentration:	0.1-100 μM
Incubation Time:	3 days
Result:	Induced dose-dependent accumulation of cells in the S and G₂phases of the cell cycle.

体内研究
(In Vivo)

LMP744 (MJ-III65) (10-50 mg/kg) administered i.v. push once a week for 4 weeks in nude mice moderately actives against human A253 and FaDu tumor xenografts without significant toxicity^[1].

Animal Model:	Athymic nude mice (nu/nu, female, 20-25 g, 8-12 weeks old) transplanted with A253 and FaDu human head and neck xenografts^[1].
Dosage:	10, 25, or 50 mg/kg/week, 4 weeks
Administration:	I.V. push via tail vein
Result:	Moderately actived against human A253 and FaDu tumor xenografts without significant toxicity.

Clinical Trial

分子量

452.46

性状

Solid

Formula

C₂₄H₂₄N₂O₇

CAS 号

308246-52-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : ≥ 4.17 mg/mL(9.22 mM)

*"≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	2.2101 mL	11.0507 mL	22.1014 mL
5 mM	0.4420 mL	2.2101 mL	4.4203 mL
10 mM	---	---	---

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。