Indotecan

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Indotecan

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

915303-09-2

包装与价格：

包装	价格(元)
1mg	电议
5mg	电议
10mg	电议
25mg	电议
50mg	电议
100mg	电议
200mg	电议

产品名称

LMP-400
NSC-724998

产品介绍

Indotecan (LMP-400)，一种茚并异喹啉衍生物，是有效的拓扑异构酶 I 抑制剂。Indotecan 抑制 P388，HCT116，和 MCF-7 细胞系的IC₅₀值分别为 300，1200，和 560 nM。Indotecan 抑制 DNA 超螺旋松弛，可用于内脏利什曼病的研究。

生物活性

Indotecan (LMP-400), an indenoisoquinoline derivative, is a potentTopoisomeraseIinhibitor, withIC₅₀s of 300, 1200, 560 nM for P388, HCT116, MCF-7 cell lines, respectively. Indotecan prevents the relaxation of supercoiled DNA and can be used for the research of visceral leishmaniasis^[1]^[2].

IC₅₀& Target^[1]

Topoisomerase I

体外研究
(In Vitro)

Indotecan (48 h) 抑制L. infantum前鞭毛体、离体感染的脾细胞和未感染的脾细胞的 IC₅₀值分别为 0.10 μM，0.10 μM，和 57.16 μM^[2]。
Indotecan (1.1-90 μM; 30 min) 诱导 TopI-DNA 共价配合物，并抑制L. infantum培养物中 DNA 合成^[2]。

体内研究
(In Vivo)

Indotecan (2.5 mg/kg; 腹腔注射每 2 天一次共 15 天) 减轻了内脏利什曼病小鼠的脾脏和肝脏中的寄生负担^[2]。

Animal Model:	Female BALB/c mice (4-6 weeks) were infected with metacyclic parasites intravenously through the tail vein^[2]
Dosage:	2.5 mg/kg body weight per injection
Administration:	Intraperitoneally every 2 days for 15 days (total, eight doses)
Result:	A drastic reduction of the number of transforming amastigotes recovered from the target organs of drug-treated animals was observed.

Clinical Trial

分子量

478.49

性状

Solid

Formula

C₂₆H₂₆N₂O₇

CAS 号

915303-09-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

溶解性数据

In Vitro:

DMSO :< 1 mg/mL (ultrasonic;warming;heat to 60℃)(insoluble or slightly soluble)