GW 590735 is a potent and selectivePPARαagonist. GW 590735 showsEC₅₀=4 nM onPPARαand at least 500-fold selectivity versusPPARδandPPARγ. GW 590735 can be used for the research of dyslipidemia^[1].

GW 590735 (0.5-5 mg/kg; orally twice a day for 5 days) is able to lower LDLc and triglycerides (TG) and increase HDL cholesterol in the Apo-A-I-transgenic mouse model (male C57BL/6 mice transgenic for human ApoA-I)^[1].
GW 590735 (intravenous administration; 2.7 mg/kg; rat) treatment shows Cl, Vd, T_1/2, andF% are 5 mL/min/kg, 1 L/kg, 2.4 hours and 47%, respectively^[1].
GW 590735 (intravenous administration; 2 mg/kg; dog) treatment shows Cl, Vd, T_1/2, andF% are 13 mL/min/kg, 2.8 L/kg, 2.6 hours and 85%, respectively^[1].

478.48

Solid

C₂₃H₂₁F₃N₂O₄S

343321-96-0

Room temperature in continental US; may vary elsewhere.

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

DMSO : 250 mg/mL(522.49 mM;Need ultrasonic)

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (protect from light)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。