Steroid sulfatase-IN-4 (Compound 16) is an irreversiblesteroid sulfatase(STS) inhibitor with anIC₅₀of 25 nM against human STS. Steroid sulfatase-IN-4 can be used for the research of endometriosis^[1].

IC₅₀: 25 nM (hSTS in cellular assays)^[1]

Steroid sulfatase-IN-4 (Compound 16) shows good metabolic stability in human hepatic S9 fraction and low intrinsic clearance Clint (<30 μlminmg protein)^[1].
Steroid sulfatase-IN-4 (20 μM; 24 h) shows cytotoxicity for HEK-293 cells (53.6% inhibition)^[1].
Steroid sulfatase-IN-4 (1 μM) shows 25% inhibition against human 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) in a cell-free assay^[1].

420.87

C₁₉H₁₇ClN₂O₅S

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.