GnRH Associated Peptide (GAP) (1-24), human is the human gonadotropin-releasing hormone-associated peptide (GAP) 1-24 fragment (hGAP-1-24). GAP is joined to the luteinizing hormone-releasing hormone (LH-RH) sequence by a 3 amino acid processing site^[1].

GAP (10 nM; 4 h) stimulates the release of both gonadotropins in anterior pituitaries from female Sprague-Dawley rats, but inhibits the basal secretion of prolactin by ~50%, compared with inhibition levels reported for dopamin, a known prolactin-inhibiting factor^[2].
GAP (0.1-10 nM; 3-4 h) inhibits prolactin secretion by 40-45%, with an IC₅₀value of 0.25 nM^[2].

2732.95

C₁₁₇H₁₉₀N₃₂O₄₃

148943-65-1

DAENLIDSFQEIVKEVGQLAETQR

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