MOG peptide(35-55)

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MOG peptide(35-55)

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2022956-48-3

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

MOG peptide (35-55) 是髓鞘少突胶质细胞糖蛋白 (MOG) 免疫原肽的 35-55 片段。MOG peptide (35-55) 特异性作用于 CD4⁺T 细胞，能够给诱导实验性自身免疫性脑脊髓炎 (EAE) 动物模型。

生物活性

MOG peptide (35-55) is a fragment 35-55 of myelin oligodendrocyteglycoprotein(MOG) immunogenic peptide. MOG peptide (35-55) is specific to expandedCD4⁺T cells, and induces experimental autoimmune encephalomyelitis (EAE) in animal model^[1]^[2]^[3].

体外研究
(In Vitro)

The expanded CD4⁺T cells are largely specific for the myelin oligodendrocyte glycoprotein (MOG) immunogenic peptide 35-55 (MOG35-55), while clonally expanded CD8⁺T cells were non-responsive to myelin peptides or proteins^[1].

体内研究
(In Vivo)

MOG peptide (35-55) (3 mg/mL for 0.1 mL; s.c.; single dose) results active induction of experimental autoimmune encephalomyelitis (EAE) in mice^[2].
MOG peptide (35-55) (200 μg; s.c.; single dose) induces a increasing concentration of the eosinophil chemoattractant eotaxin-1 in the spinal cord in the course of EAE induced in C57BL/6 mice^[3].

Animal Model:	129S1/SvImJ, C57BL/6 and C57BL/6 X SJL hybrid^[2]
Dosage:	3 mg/mL, 0.1 mL per mice; accompanied with CFA and 4 mg/mLMycobacterium tuberculosis
Administration:	Subcutaneous injection; single dose
Result:	Showed the expected signs of experimental autoimmune encephalomyelitis (EAE), which started with tail loss of tonus and continued in an ascending fashion in mice immunized with MOG35-55.

Animal Model:	C57BL/6 mice (8-12 weeks)^[3]
Dosage:	200 μg
Administration:	Subcutaneous injection; single dose; analyzed at pre-onset (day 7 post immunization), onset (day 9-13 post immunization) and peak (day 17-19 post immunization)
Result:	Increased eosinophil abundance in the spinal cord increases in the course of EAE.

分子量

2580.97

Formula

C₁₁₈H₁₇₈N₃₆O₂₈S

CAS 号

2022956-48-3

Sequence Shortening

MEVGWYRSPFSRVVHLYRNGK-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.