Nrf2 activator-2 (compound O15), a Osthole derivative, is a potentNrf2agonist with anEC₅₀of 2.9 μM in 293 T cells. Nrf2 activator-2 effectively inhibits the interaction between Keap1 and Nrf2, thus showing the activation effect on Nrf2. Nrf2 activator-2 shows a marked decrease in the level of ubiquitinated Nrf2 in cells^[1].

385.25

C₂₀H₁₇BrO₃

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