3-Hydroxykynurenine 是一种色氨酸代谢物，是潜在的内源性神经毒素，在几种神经退行性疾病中表达水平都有升高的现象。3-Hydroxykynurenine 诱导神经细胞凋亡 (apoptosis)。
| 生物活性 | 3-Hydroxykynurenine, a metabolite of tryptophan, is a potential endogenous neurotoxin whose increased levels have been described in several neurodegenerative disorders. 3-Hydroxykynurenine induces neuronalapoptosis[1]. |
| IC50& Target | Human Endogenous Metabolite |
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体外研究
(In Vitro) | 3-Hydroxykynurenine-induced neuronal cell death shows several features of apoptosis[1].
3-Hydroxykynurenine is a metabolic intermediate of the kynurenine pathway, the major metabolic pathway of tryptophan (Trp)[1].
3-Hydroxykynurenine acts as an endogenous neurotoxin in the brain under pathological conditions[1].
3-Hydroxykynurenine (20-100 μM) significantly inhibits CD4+ T-cell proliferation in a dose-dependent manner with IC50 of approximately 70 μM[2].
3-Hydroxykynurenine (20-100 μM) induces significant CD4+ T-cell-mediated cell death in a dose-dependent manner[2].
Cell Proliferation Assay[2] | Cell Line: | CD3/CD28 bead-stimulated CD4+ T cells | | Concentration: | 0, 20, 40, 60, 80, and 100 μM | | Incubation Time: | 72 hours | | Result: | Significantly inhibited CD4+ T-cell proliferation in a dose-dependent manner with an IC50 of approximately 70 μM. |
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体内研究
(In Vivo) | 3-Hydroxykynurenine administration (560 mg/kg IP on a daily basis on days 1 to 7, days 7 to 14, or days 1 to 14) results in significant prolongation of graft survival whether administered between days 1 to 7, days 7 to 14, or days 1 to 14[2].
| Animal Model: | BALB/c (H2d) mice[2] | | Dosage: | 560 mg/kg | | Administration: | IP injection | | Result: | There was significant prolongation of graft survival in all treatment groups in comparison to the controls. |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | | Powder | -20°C | 3 years | | 4°C | 2 years | | In solvent | -80°C | 6 months | | -20°C | 1 month |
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| 溶解性数据 | In Vitro: 1M HCl : 33.33 mg/mL(148.66 mM;ultrasonic and adjust pH to 1 with HCl) 配制储备液 | 1 mM | 4.4601 mL | 22.3005 mL | 44.6010 mL | | 5 mM | 0.8920 mL | 4.4601 mL | 8.9202 mL | | 10 mM | 0.4460 mL | 2.2301 mL | 4.4601 mL |
*请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。 |
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