PD-1/PD-L1-IN-24 is a highly potentPD-1/PD-L1inhibitor withIC₅₀value of 1.57 nM. PD-1/PD-L1-IN-24 can restore T-cell function at the cellular level by significantly elevating theIFN-γlevel. PD-1/PD-L1-IN-24 has low toxicity on the PBMCs^[1].

IC₅₀: 1.57 nM (PD-1/PD-L1)^[1]

PD-1/PD-L1-IN-24 (compound 39) (0-10 μM; 6 hours) significantly releases PD-L1-mediated inhibition of PD-1-expressing Jurkat T cells at the concentration of 10 μM^[1].
PD-1/PD-L1-IN-24 (0.003-20 μM; 72 hours) exhibits no significant toxicity at concentrations ranging from 0.003 to 2.22 μM, and the IC₅₀is 12.42 μM^[1].
PD-1/PD-L1-IN-24 (0.082, 0.247, 0.741 and 2.222 μM; 72 hours) significantly elevates the secretion of IFN-γ with a dose-dependent manner in T cell-tumor co-culture cells^[1].

640.08

C₃₄H₃₀ClN₅O₆

2667680-33-1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.