LSD1/2-IN-4, a PCPA derivative, is an inhibitor oflysine-specific demethylase 1 (LSD1) and lysine-specific demethylase 2 (LSD2). LSD1/2-IN-4 inhibits LSD1 and LSD2 withK_ivalues of 0.11 μM and 130 μM, respectively. LSD1/2-IN-4 can be used for the research of several cancers including T-cell acute lymphoblastic leukemia (TALL)^[1].

Ki: 0.11 μM (LSD1); 130 μM (LSD2)^[1]

LSD1/2-IN-4 shows strong inhibitory activity against both LSD1 and LSD2 with K_ivalues of 0.11 μM and 130 μM, respectively and not inhibits peroxidase with an IC₅₀>500 μM^[1].

248.07

C₉H₈BrF₂N

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.