cis-Mulberroside A

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cis-Mulberroside A

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

166734-06-1

包装与价格：

包装	价格(元)
5mg	电议
10mg	电议
25mg	电议

产品名称

Mulberroside D

产品介绍

cis-Mulberroside A (Mulberroside D) 是 Mulberroside A 的顺式异构体。Mulberroside A 是桑树 (Morus albaL.) 中的主要生物活性成分之一。Mulberroside A 可降低TNF-α，IL-1β和IL-6的表达，抑制 NALP3，caspase-1 和 NF-κB 的激活以及 ERK，JNK 和 p38 的磷酸化。Mulberroside A 具有抗炎和抗细胞凋亡作用。Mulberroside A 对蘑菇酪氨酸酶 (tyrosinase) 具有抑制活性，IC₅₀为 53.6 μM。

生物活性

cis-Mulberroside A (Mulberroside D) is the cis-isomer of Mulberroside A. Mulberroside A is one of the main bioactive constituent in mulberry (Morus albaL.)^[1]. Mulberroside A decreases the expressions ofTNF-α,IL-1β, andIL-6and inhibits the activation of NALP3,caspase-1, andNF-κBand the phosphorylation ofERK,JNK, and p38, exhibiting anti-inflammatory and anti-apoptotic effects^[2]. Mulberroside A shows inhibitory activity against mushroomtyrosinasewith an IC₅₀of 53.6 μM^[3].

体内研究
(In Vivo)

Mulberroside A (10, 20, and 40 mg/kg) decreases serum uric acid levels and increases urinary urate excretion and fractional excretion of uric acid in hyperuricemic mice^[4].

Animal Model:	Male Kun-Ming mice (20±2 g)^[4]
Dosage:	5, 10, 20, and 40 mg/kg; the dose volume 10 mL/kg body weight
Administration:	Orally initiated at 9:00 a.m.
Result:	10, 20, and 40 mg/kg significantly increased urinary urate excretion in 24 h, resulting in a remarkable elevation of fractional excretion of uric acid (FEUA), and the highest dose completely reversed FEUA alteration of hyperuricemic mice to normal.

分子量

568.52

Formula

C₂₆H₃₂O₁₄

CAS 号

166734-06-1

结构分类

Phenols
Polyphenols

Stilbenes

来源

Plants
Moraceae
Morus albaLinn.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.