CCZ01048, a α-melanocyte-stimulating hormone (α-MSH) analogue, exhibits high binding affinity to melanocortin 1 receptor(MC1R)with aK_iof 0.31 nM. CCZ01048 shows rapid internalization into B16F10 melanoma cells and high in vivo stability. CCZ01048 is a promising candidate for PET imaging of malignant melanoma^[1].

The cationic Pip linker to Nle-CycMSHhex, CCZ01048, not only improves tumor uptake, but also generates high tumor-to-normal tissue contrast with PET imaging in a preclinical melanoma model^[1].

1508.72

C₇₁H₁₀₅N₂₁O₁₆

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.