Unoprostone, a prostaglandin F2α analogs (PGAs), activatesBK channelsto reduce oxidative stress- and light-induced retinal cell death, and phagocytotic dysfunction. Unoprostone reduces intraocular pressure and is used topically for glaucoma or ocular hypertension^[1].

Pretreatment with Unoprostone (0.01, 0.1, 1 μM; 1 h before H₂O₂treatment) protects against H₂O₂-induced cell death in a concentration-dependent manner and the effect is significant at 0.1 μM and 1 μM concentrations^[1].
Pretreatment with Unoprostone at concentrations of 0.1 to 3 μM protects against light-induced cell death in a concentration-dependent manner; the effect is significant at the 1 and 3 μM concentrations. Unoprostone reduces the morphological change, and it significantly inhibits the low mitochondrial membrane potential and cell death induced by light irradiation^[1].
Unoprostone has prostaglandin F_2αreceptors (FP) binding affinity with a K_iof 3.86 μM^[2].

Unoprostone (0.06%, 0.12%; topical instillation; 3 μl) reduces mouse intraocular pressure (IOP) in a dose-dependent manner^[3].

382.53

C₂₂H₃₈O₅

120373-36-6

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.