Glucagon (1-29), bovine, human, porcine hydrochloride is a peptide hormone, produced by pancreatic α-cells. Glucagon hydrochloride stimulates gluconeogenesis^[1]. Glucagon (1-29), bovine, human, porcine hydrochloride activates HNF4α and increases HNF4α phosphorylation^[2][3].

Upon binding to its receptor Gcgr, Glucagon activates cAMP-PKA signaling to stimulate hepatic glucose production (HGP) and cause hyperglycemia^[1].
Glucagon stimulates both hepatic kisspeptin1 production and gluconeogenesis^[1].
Glucagon (100 nM) represses CYP7A1 mRNA expression in human primary hepatocytes^[3].
Glucagon (100 nM) increases phosphorylayion of HNF4α^[3].

Low-dose (20 μg/kg) Glucagon increases glycemia and does not stimulate insulin secretion in ambient-fed mice. High-dose (1 mg/kg) Glucagon lowers glycemia compared with PBS control and stimulates insulin secretion in ambient-fed mice^[4].

3519.21

C₁₅₃H₂₂₅N₄₃O₄₉S.ClH

28270-04-4

His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr

HSQGTFTSDYSKYLDSRRAQDFVQWLMNT

盐酸胰高血糖素

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.