Raloxifene

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Raloxifene

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

84449-90-1

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品名称

Keoxifene
LY156758 free base
LY139481

产品介绍

Raloxifene (Keoxifene) 是一种苯并噻吩类选择性雌激素受体 (estrogen receptor) 调节剂 (SERM)，对骨、血脂有雌激素激动作用，对乳腺和子宫有雌激素拮抗作用。Raloxifene 用于乳腺癌和骨质疏松症研究。

生物活性

Raloxifene (Keoxifene) is a benzothiophene-derived selectiveestrogen receptormodulator (SERM). Raloxifene has estrogen-agonistic effects on bone and lipids and estrogen-antagonistic effects on the breast and uterus. Raloxifene is used for breastcancerand osteoporosis research^[1].

IC₅₀& Target

Estrogen receptor

体内研究
(In Vivo)

Raloxifene (4 mg/kg; intragastrically; daily for 13 weeks) significantly prevents bone loss in ovariectomized (OVX) rats^[1].

Animal Model:	Female, 12-week-old, Wistar rats (OVX rats)^[1]
Dosage:	4 mg/kg
Administration:	Intragastrically; daily for 13 weeks
Result:	Significantly increased the levels of E2 in OVX rats and significantly decreased the levels of BGP.

Clinical Trial

分子量

473.58

Formula

C₂₈H₂₇NO₄S

CAS 号

84449-90-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.