TEI-9648

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TEI-9648

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

173388-21-1

包装与价格：

包装	价格(元)
1mg	电议
5mg	电议
10mg	电议
50mg	电议
100mg	电议

产品介绍

TEI-9648 是一种 Vitamin D₃Lactone 类似物，是有效的，特异性的维生素 D 受体 (VDR) 拮抗剂。TEI-9648 抑制 VDR/VDRE 介导的 1α,25(OH)₂D₃的基因组作用。TEI-9648 也可以抑制 1α,25(OH)₂D₃诱导的 HL-60 细胞分化。TEI-9648 有潜力用于骨代谢的研究。

生物活性	TEI-9648, a Vitamin D₃Lactone analogue, is a potent and specificvitamin D receptor (VDR)antagonist. TEI-9648 inhibits VDR/VDRE-mediated genomic actions of 1α,25(OH)₂D₃. TEI-9648 also inhibits HL-60 cell differentiation induced by of 1α,25(OH)₂D₃. TEI-9648 has the potential for bone metabolism research^[1]^[2].
体外研究 (In Vitro)	TEI-9648 (10-1000 nM) dose-dependently blocks the reciprocal changes of CD11b and CD71 expression associated with HL-60 cell differentiation induced by 1α,25(OH)₂D₃^[1]. TEI-9648 has consistently weaker suppressive effect than TEI-9647^[1]. TEI-9648 can not induce cell differentiation even after treatment at 1 μM in HL-60 cell^[1]. TEI-9648 alone can not induce activation of NBT-reducing activity or α-NB esterase activity. In contrast, TEI-9648 markedly suppresses the up-regulation induced by 1α,25(OH)₂D₃(0.1 nM) in HL-60 cells^[1].
分子量	426.59
性状	Solid
Formula	C₂₇H₃₈O₄
CAS 号	173388-21-1
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, protect from light, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)