Z-Ile-Leu-aldehyde

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Z-Ile-Leu-aldehyde

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

161710-10-7

包装与价格：

包装	价格(元)
10 mM * 1 mL in DMSO	电议
2mg	电议
5mg	电议
10mg	电议
50mg	电议
100mg	电议

产品名称

Z-IL-CHO
GSI-XII
γ-Secretase inhibitor XII

产品介绍

Z-Ile-Leu-aldehyde (Z-IL-CHO) 是有效的、竞争性的γ-secretase和notch的肽醛抑制剂。

生物活性

Z-Ile-Leu-aldehyde (Z-IL-CHO) is a potent and competitive peptide aldehyde inhibitor ofγ-secretaseandnotch^[1]^[2].

体外研究
(In Vitro)

Z-Ile-Leu-aldehyde (ILCHO) significantly downregulates Th17-associated cytokine levels in murine Th17 in vitro polarization assays^[1].
Z-Ile-Leu-aldehyde (GSI XII) induces apoptosis of murine MOPC315.BM myeloma cells with high Notch activity^[2].

RT-PCRsup>[1]

Cell Line:	CD4⁺T cells from C57BL/6 mice.
Concentration:	25 μM.
Incubation Time:	24, 48, 72 hours.
Result:	DownregulateD ROR?t and IL-17 mRNA expression.

Cell Viability Assaysup>[2]

Cell Line:	MOPC315.BM cells.
Concentration:	0, 12, 15 μM.
Incubation Time:	24-48 h hours.
Result:	Reduced viability and induced apoptosis in MOPC315.BM cells

体内研究
(In Vivo)

Z-Ile-Leu-aldehyde (GSI XII, 10 mg/kg, Intraperitoneally either for 14 days) controls myeloma bone disease mainly by targeting Notch in MM cells and possibly in osteoclasts in their microenvironment^[2].

Animal Model:	MOPC315.BM mouse model^[2].
Dosage:	10 mg/kg.
Administration:	Intraperitoneally either for 14 days.
Result:	Reduces myeloma-specific paraprotein levels in the MOPC315.BM model. Diminished osteolytic lesions in the MOPC315.BM mice.

分子量

362.46

性状

Solid

Formula

C₂₀H₃₀N₂O₄

CAS 号

161710-10-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : ≥ 41 mg/mL(113.12 mM)

*"≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	2.7589 mL	13.7946 mL	27.5893 mL
5 mM	0.5518 mL	2.7589 mL	5.5179 mL
10 mM	0.2759 mL	1.3795 mL	2.7589 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。