Foxy-5, aWNT5Aagonist, is a mimicking peptide of WNT5A which is a non-canonical member of theWntfamily. Foxy-5 triggers cytosolic free calcium signaling without affectingβ-cateninactivation and it impairs the migration and invasion of epithelialcancercells. Foxy-5 effectively reduces the metastatic spread of WNT5A-low prostatecancercells in an orthotopic mouse model^[1][2][3][4].

WNT5A^[2]

Foxy-5 effectively reduces the metastatic spread of WNT5A-low prostate cancer cells in an orthotopic mouse model^[1].
Foxy-5 reduces the number of colonic cancer stem cells in a xenograft mouse model of human colonic cancer^[2].

694.77

C₂₆H₄₂N₆O₁₂S₂

881188-51-8

MDGCEL

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