Sulprostone (SHB 286) is a potent and selectiveEP3 receptoragonist. Sulprostone (SHB 286) is a prostaglandin E2 (PGE2) analogue and has antiulcer and nonsteroidal abortifacient effects. Sulprostone has potential for the research of pregnancy termination and hemorrhages during delivery^[1][2][3].

Sulprostone (SHB 286) has K_ivalues of 21 nM and 0.6 nM for EP1 and EP3 in cultured Chinese hamster ovary cells^[1].
Sulprostone (1, 1.5 or 2 mg/mL) does not significantly modify the viability and the purity of Dendritic cells (DCs). Sulprostone impairs spontaneous and directed DC migration independently from its concentration. Sulprostone reduces the expression of CCR7 and impairs migration of DCs^[2].

Sulprostone (SHB 286; 0.5 mg/kg; IV) has a T_1/2of 0.451 hours, a CL of 56 mL/minokg, a V_ssof 0.583 L/kg and an AUC of 149 ngoh/mL^[3].

465.56

Liquid

C₂₃H₃₁NO₇S

60325-46-4

硫前列酮

Room temperature in continental US; may vary elsewhere.

Solution, -20°C, 2 years