| CAS NO: | 1037210-93-7 |
| 包装: | 5mg |
| 市场价: | 23800元 |
| 生物活性 | Saridegib is a potent and specific inhibitor of Smoothened(Smo), a key signaling transmembrane protein in theHedgehog(Hh) pathway. | ||||||||||||
| IC50& Target | Smo[1]. | ||||||||||||
| 体内研究 (In Vivo) | Evidence from a genetically engineered mouse model of pancreatic cancer demonstrates that Saridegib (IPI-926) can deplete tumor-associated stromal tissue and increase intratumoral mean vessel density. These changes result in enhanced delivery of concurrently administered systemic agents, leading to a decreased tumor burden and prolonged survival in this mouse model[1]. | ||||||||||||
| Clinical Trial | |||||||||||||
| 分子量 | 504.77 | ||||||||||||
| 性状 | Solid | ||||||||||||
| Formula | C29H48N2O3S | ||||||||||||
| CAS 号 | 1037210-93-7 | ||||||||||||
| 运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| 储存方式 |
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