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Robotnikinin
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Robotnikinin图片
CAS NO:1132653-79-2
包装与价格：
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
Robotnikinin 是一个能够结合和抑制 Smo上游Sonic Hedgehog (Shh)信号的小分子。
生物活性

Robotnikinin is a small molecule capable of binding to and inhibiting the activity ofSonicHedgehog(Shh)signaling up stream ofSmo[1][2].

体外研究
(In Vitro)

Robotnikinin demonstrates ShhN-binding capacity at concentrations between 1.56 μM and 25 μM, with a KDof 3.1 μM derived from kinetic data[2].
Robotnikinin (50 μM) prevents the ShhN-induced LC3-II increase[3].
Robotnikinin (5 μM) downregulates classical NF-κB pathway proteins in H929 and U266 cell lines cocultured with HS-5 cells, suggesting a link between Hh signaling and the NF-κB pathway in MM[4].

RT-PCR[4]

Cell Line:NCI-H929 or U266 cells.
Concentration:5 μM.
Incubation Time:48 h.
Result:Downregulated classical NF-κB pathway proteins in H929 and U266 cell lines cocultured with HS-5 cells.
分子量

454.95

Formula

C25H27ClN2O4

CAS 号

1132653-79-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.