AG 370, an indole tyrphostin, is a potentPDGF-induced mitogenesis inhibotor (IC₅₀of 20 μM). AG 370 displays weak inhibition of theEGFreceptor^[1].

AG 370 blocks mitogenesis induced by epidermal growth factor (IC₅₀of 50 μM) and human serum (IC₅₀of 50 μM)^[1][1].
In Digitonin-permeabilized fibroblasts as well as in intact fibroblasts, tyrphostin AG 370 inhibits PDGF receptor autophosphorylation and the tyrosine phosphorylation of intracellular protein substrates (pp120, pp85, and pp75) which coprecipitate with the PDGF receptor^[1][1].

259.27

C₁₅H₉N₅

134036-53-6

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.