HNMPA is a membrane impermeableinsulin receptortyrosine kinaseinhibitor. HNMPA inhibits serine and tyrosine autophosphorylation by the humaninsulin receptor. HNMPA has no effect on protein kinase C or cyclic AMP-dependent protein kinase activities^[1][2]

HNMPA inhibits the phosphorylation of a synthetic peptide substrate composed of insulin receptor residues 1290-1319 on serines-1305/1306 by partially purified insulin receptors^[1].
HNMPA blocks GABA-dependent insulin inhibition, and reduces neuronal firing after GABA application^[2].

238.18

C₁₁H₁₁O₄P

132541-52-7

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