PROTAC BRD4 Degrader-2

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2185795-53-1

包装与价格：

产品介绍

PROTAC BRD4 Degrader-2 是由Cereblon配体和BRD4配体相连的PROTAC，对BRD4 BD1的IC₅₀为 14.2 nM。

生物活性

PROTACBRD4 Degrader-2 is aPROTACconnected by ligands forCereblonandBRD4with anIC₅₀of 14.2 nM againstBRD4BD1^[1].

IC₅₀& Target^[1]

BRD4 BD1

14.2 nM (IC₅₀)

Cereblon

体外研究
(In Vitro)

PROTAC BRD4 Degrader-2 (Compound 17) inhibits the growth of THP-1 cell line with an IC₅₀of 1.83±0.016 μM^[1].

Cell Proliferation Assay^[1]

Cell Line:	Human monocyte lymphoma cell line THP-1
Concentration:	72 hours
Incubation Time:	0.81-3.26 μM
Result:	Showd high anti-proliferative potency.

分子量

757.79

Formula

C₄₀H₃₉N₉O₇

CAS 号

2185795-53-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.