Mizoribine

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Mizoribine

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

50924-49-7

包装与价格：

包装	价格(元)
10mg	电议
25mg	电议
50mg	电议
100mg	电议

产品介绍

Mizoribine (NSC 289637) 抑制?HCV?RNA 复制，具有抗 HCV 活性，IC50?约为 100 μM。Mizoribine 是一种免疫抑制剂。Mizoribine 抑制?IMPDH。Mizoribine 抑制?SARS-CoV?复制，对 SARS-CoV Frankfurt-1 和 SARS-CoV HKU39849 的 IC50?分别为 3.5 μg/mL 和 16 μg/mL。

Cas No.	50924-49-7
别名	咪唑立宾; NSC 289637; HE 69
化学名	1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-hydroxyimidazole-4-carboxamide
Canonical SMILES	C1=NC(=C(N1C2C(C(C(O2)CO)O)O)O)C(=O)N
分子式	C₉H₁₃N₃O₆
分子量	259.22
溶解度	≥ 88.2mg/mL in DMSO
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	Mizoribine (NSC 289637; HE 69), an imidazole nucleoside, has been used as an immunosuppressive agent. Mizoribine (NSC 289637; HE 69) also is an Hsp60 inhibitor. References: [1]. Ishikawa H. Mizoribine and mycophenolate mofetil. Curr Med Chem. 1999 Jul;6(7):575-97. [2]. Aizawa T, et al. Mizoribine selectively attenuates monocyte chemoattractant protein-1 production in cultured human glomerular mesangial cell: A possible benefit of its use in the treatment of lupus nephritis. Nephrology (Carlton). 2014 Jan;19(1):47-52. [3]. Zhang M, et al. Study of the efficacy of mizoribine in lupus nephritis in Chinese patients. Rheumatol Int. 2013 Nov;33(11):2737-42.