Biotin-PEG3-C3-NH2 is a PEG-basedPROTAClinker, with NH₂functional group, that can be used in the synthesis ofPROTACs^[1].

PROTAC linkers exert function for connecting the two different ligands that make up PROTACs, the two ligands are E3 ubiquitin ligase and the target protein, respectively^[1].
PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].
PROTAC can significantly attenuate tumor progression in tumor xenografts^[1].
Biotin-PEG3-C3-NH2 (compound 11) (0-2 mM; 3 h) combinded with protein G (compound 6) displays fluorescence under streptavidin probes, Biotin-PEG3-C3-NH2 is a powerful tool for the high-throughput analysis of protein-small molecule interaction and profiling enzyme activities in a microarrays constructed by surface derivatization method^[3].

446.60

Oil

C₂₀H₃₈N₄O₅S

183896-00-6

Room temperature in continental US; may vary elsewhere.

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)