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Physcion
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Physcion图片
CAS NO:521-61-9
包装:20mg
市场价:641元

产品介绍
Physcion (Parietin) 是一种从中药大黄中分离出来的蒽醌，作为 6-磷酸葡萄糖酸脱氢酶的抑制剂，IC50 和 Kd 分别为 38.5 μM 和 26.0 μM。
Cas No.521-61-9
别名大黄素甲醚; Parietin; Rheochrysidin
化学名1,8-dihydroxy-3-methoxy-6-methylanthracene-9,10-dione
Canonical SMILESCC1=CC(=C2C(=C1)C(=O)C3=CC(=CC(=C3C2=O)O)OC)O
分子式C16H12O5
分子量284.27
溶解度≥ 1.42mg/mL in DMSO with ultrasonic and warming
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Physcion (Parietin) is an anthraquinone isolated from traditional Chinese medicine Radix et Rhizoma Rhei, acts as an inhibitor of 6-phosphogluconate dehydrogenase, with an IC50 and a Kd of 38.5 μM and 26.0 μM, respectively[1][2]. Physcion (Parietin) exhibits laxative, hepatoprotective, anti-inflammatory, anti-microbial, anti-proliferative and anti-tumor effects[2].

References:
[1]. Lin R, et al. 6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling. Nat Cell Biol. 2015 Nov;17(11):1484-96.
[2]. Pang MJ, et al. Physcion, a naturally occurring anthraquinone derivative, induces apoptosis and autophagy in human nasopharyngeal carcinoma. Acta Pharmacol Sin. 2016 Dec;37(12):1623-1640.