凋亡加强结构域蛋白15样蛋白抗体产品名称 Anti-NLRC3 Anti-NLR family CARD domain containing 3 Antibody 产品介绍
靶标: NLRC3 产品别名: CLR16.2; NOD3; NLRC3; NLR family CARD domain containing 3; NLR family CARD domain containing 3; NLR family CARD domain-containing protein 3; CARD15-like protein; NACHT, LRR and CARD domains-containing protein 3; NOD-like receptor C3; caterpiller protein 16.2; nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 3; 凋亡加强结构域蛋白15样蛋白; 背景信息: NOD3 is a member of the NOD (nucleotide-binding oligomerization domain) family, a group of proteins that are involved in innate immune defense. NOD3 also known as NLR family CARD containing 3 (NLRC3), is predominantly expressed in the immune system, particularly in T lymphocytes, and its expression is strongly down-regulated following stimulation of the T-cell receptor complex and CD28, suggesting that NOD3 plays a role in attenuating the activation of T cells. NOD3 inhibits NF-κB, AP-1 and NFAT transcriptional activation in Jurkat T cells downstream of CD3/CD28 stimulation or treatment with PMA/ionomycin and decreases IL-2 and CD25 mRNA induction in activated cells. 宿主:Rbt 用户评论 产品评分 目前评分共0人 产品质量
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