LRRC46 (Leucine-Rich Repeat Containing 46) is located on human chromosome 17q21.32. The LRRC46 protein is biasedly expressed in testis and lung. Structurally, the encoded LRRC46 protein is reported to be 35340 Da in mass. The LRRC46 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, and chicken. 163 organisms have orthologs with human gene LRRC46. LRRC46 is associated with some diseases, such as Primary Ciliary Dyskinesia. An important paralog of this gene is LRGUK.