TMEM143 (Transmembrane Protein 143) is located on human chromosome 19q13.32. The TMEM143 protein is ubiquitously expressed in heart, fat and other tissues. Structurally, the encoded protein is reported to be 51715 Da in mass. The TMEM143 (also known as FLJ10922) gene is conserved in chimpanzee, dog, cow, mouse, rat, and frog. 132 organisms have orthologs with human gene TMEM143. An important paralog of this gene is PROSER2.