Hydrolases are transported to lysosomes after binding to mannose 6-phosphate receptors inThe trans-Golgi network.This gene encodesThe enzyme that catalyzesThe second step inThe formation ofThe mannose 6-phosphate recognition marker on lysosomal hydrolases. Commonly known as 'uncovering enzyme' or UCE,This enzyme removes N-acetyl-D-glucosamine (GlcNAc) residues from GlcNAc-alpha-P-mannose moieties andThereby producesThe recognition marker.This reaction most likely occurs inThe trans-Golgi network.This enzyme functions as a homotetramer of two disulfide-linked homodimers. In addition to having an N-terminal signal peptide,The protein's C-terminus contains multiple signals for trafficking it between lysosomes,The plasma membrane, and trans-Golgi network. [provided by RefSeq, Jul 2008]