肌萎缩侧索硬化症相关蛋白HECW1抗体
 产品名称 Anti-HECW1 Anti-HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 Antibody 产品介绍
靶标： HECW1 产品别名： NEDL1； HECW1； HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1； HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1； E3 ubiquitin-protein ligase HECW1； HECT type E3 ubiquitin ligase； HECT-type E3 ubiquitin transferase HECW1； NEDD4-like ubiquitin-protein ligase 1； 肌萎缩侧索硬化症相关蛋白HECW1； 背景信息： function:E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS.,pathway:Protein modification; protein ubiquitination.,similarity:Contains 1 C2 domain.,similarity:Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.,similarity:Contains 2 WW domains.,subunit:Interacts with DVL1 and SSR3. Also interacts with mutant SOD1.,tissue specificity:Predominantly expressed in neurons of adult and fetal brain. Weakly expressed in the kidney., 宿主：Rbt 用户评论 产品评分 目前评分共0人 产品质量
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