CAS 99646-28-3; (R)-(+)-2,2'-bis(di-p-tolylphosphino)-1,1'- binaphthyl

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R817329

MACKLIN

(|R|)-(+)-2,2'-联[二-(4-甲基苯基)膦基]-1,1'-联萘

98%

54元/250mg; 192元/1g; 799元/5g; 3500元/25g;

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储存：室温
状态：白色晶体粉末

T3152

TCI

(R)-(+)-TolBINAP

>98.0%(HPLC)

790元/1G; 2795元/5G;

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基本信息

纯度/分析方法	>98.0%(HPLC)
分子式/分子量	C₄₈H₄₀P₂ = 678.80
外观与形状(20℃)	固体
储存在惰性气体下	存放于惰性气体之中
应避免的情况	空气
Reaxys-RN	5786040
PubChem物质ID	253661839
MDL编号	MFCD01311709

技术规格

Appearance	White to Almost white powder to crystal
Purity(HPLC)	min. 98.0 area%
Optical purity(LC)	min. 99.0 ee%

物性(参考值)

熔点	258 ℃
最大吸收波长	223(EtOH) nm
水溶性	不溶

15-0152

Strem

(R)-(+)-2,2'-Bis(di-p-tolylphosphino)-1,1'-binaphthyl

98%

450元/250mg; 1002元/1g; 4003元/5g;

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Technical Notes:

1.See 15-01 50

2.UsefuI ligand for palladium-catalyzed carbon-oxygen bond formation.

3.Ligand for palladium-catalyzed a-arylation of ketones .

4.Ligand for Cu-catalyzed asymmetric conjugate reduction.

5.Ligand for Cu-catalyzed asymmetric dienolate addition to aldehydes.

6.Enantioselective conjugate reduction of lactones and lacta ms.

7. Ligand used in the enantioselective cycloaddition of allenyIsilanes with a-lmino esters.

8. Catalytic AldoI reaction to ketones.

9. L igand with rhodium catalyses 2+2+2 cycloaddition reaction of alkenes and alkynes .

10.Ligand used in the copper catalyzed asymmetric conjugate addition of alkyl Grignard reagents on a,ß-unsaturated esters.

11. Ligand used in the copper-catalyzed asymmetric synthesis of cyclopropanes via tandem conjugate

addition and intramolecular enolate trapping.

042119

Alfa Aesar

(R)-(+)-2,2'-Bis(di-p-tolylphosphino)-1,1'-binaphthyl

98%

506元/100mg; 1859元/0.5g; 7432元/2g; 16815元/10g;

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应用
(R)-(+)-2,2'-Bis(di-p-tolylphosphino)-1,1'-binaphthyl is used as chiral catalyst ligand. (R)-T-BINAP complexes derived from rhodium precursors are used for the asymmetric hydroformylation of vinyl acetate. It is a catalysts used for reductive amination of ketones, Pt dications for cation trapping, Rh(I)-catalyst for hydrogenation of acetamidoacrylic acid derivatives.

备注
Store in cool, dry place in tightly closed container. Store away from oxidizing agents.

基本信息

MDL
MFCD00269856

分子式
C₄₈H₄₀P₂

分子量
678.79

熔点
255-257°

灵敏度
Ambient temperatures.

形态
Powder

溶解性
Insoluble in water.

GHS危害和防范说明

GHS符号

Hazard Statements
H315-H319-H335
Causes skin irritation.Causes serious eye irritation.May cause respiratory irritation.

Precautionary Statements
P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray.Wear protective gloves and eye/face protection.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.

安全信息

危险类别
36/37/38
Irritating to eyes, respiratory system and skin.

安全等级
26-37
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

TSCA
否

693049

Sigma-Aldrich

(R)-Tol-BINAP

626.83元/500 MG;

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产品说明

一般描述

BINAP 是基于双萘主链与不同的膦衍生物。2,2′-双(二-p-甲苯基膦)-1,1′-联萘 (p-Tol-BINAP) ·AgF 络合物催化的不对称 Mukaiyama 型羟醛缩合反应。

应用

用于不对称反应的 Takasago 配体和复合物
过量膦配体在乙基溴化镁与 α,β-不饱和酯对映选择性共轭加成反应中作用的催化剂研究

用作以下物质前体的反应物：

酮还原胺化反应用催化剂
Rh (I)-乙酰胺基丙烯酸衍生物加氢催化剂
手性铂催化剂催化环酮的不对称 Baeyer-Villiger 氧化
CuI-Tol-BINAP 催化格氏试剂对映选择性 Michael 反应
阳离子捕获的 BINAP Pt 描述

由铑前体衍生的 ( R )-T-BINAP 复合物用于醋酸乙烯的不对称氢甲酰化。它可以用作手性催化剂，用于烯丙基化 N-基甲基α-亚氨基酯。

包装

100, 500 mg in amber glass bottle

法律信息

与 Takasago 联合销售，仅供研究使用。

基本信息

经验(实验)分子式	C₄₈H₄₀P₂
分子量	678.78
MDL编号	MFCD01311709
PubChem化学物质编号	329761557
NACRES	NA.22

产品性质

旋光性	[α]20/D +162°, c = 0.5 in benzene
质量水平	100
reaction suitability	reaction type: Buchwald-Hartwig Cross Coupling Reaction reaction type: Heck Reaction reaction type: Hiyama Coupling reaction type: Negishi Coupling reaction type: Sonogashira Coupling reaction type: Stille Coupling reaction type: Suzuki-Miyaura Coupling reagent type: catalyst reaction type: Cross Couplings
mp	254-258 ℃
官能团	phosphine
SMILES string	Cc1ccc(cc1)P(c2ccc(C)cc2)c3ccc4ccccc4c3-c5c(ccc6ccccc56)P(c7ccc(C)cc7)c8ccc(C)cc8
InChI	1S/C48H40P2/c1-33-13-23-39(24-14-33)49(40-25-15-34(2)16-26-40)45-31-21-37-9-5-7-11-43(37)47(45)48-44-12-8-6-10-38(44)22-32-46(48)50(41-27-17-35(3)18-28-41)42-29-19-36(4)20-30-42/h5-32H,1-4H3
InChI key	IOPQYDKQISFMJI-UHFFFAOYSA-N

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable