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关键词:       仅模糊查询
CAS: 99011-02-6
分子式: C14H16N4
分子量: 240.31
中文名称: 
1-(2-甲基丙基)-4-氨基-1H-咪唑并[4,5-C]喹啉
1-异丁基-1H-咪唑[4.5-C]喹啉-4-胺基
咪喹莫特
英文名称: 
Aldara
1-isoButyl-1H-Inudazole[4.5-c]quinoline-4-amine
1-(2-methylpropyl)-1H-imidazo(4,5-quinolin-4-amine)
Imiquimod
s 26308
用途: 抗尖锐湿疣、免疫调节剂
推荐供应商
货号品牌产品名称规格包装、参考价格详情
I838239MACKLIN咪喹莫特≥98% HPLC, solid30元/50mg;   49元/250mg;   91元/1g;   325元/5g;   1299元/25g;   3899元/100g;   展开
储存：室温
状态：白色到淡黄色固体
I797950MACKLIN咪喹莫特2mM in DMSO780元/1ml;   展开
储存：-20°C
I0747TCIImiquimod>98.0%(T)(HPLC)540元/100MG;   1750元/1G;   展开

基本信息

纯度/分析方法>98.0%(T)(HPLC)
分子式/分子量C14H16N4 = 240.31
外观与形状(20℃)固体
Reaxys-RN7710060
PubChem物质ID87561300
Merck Index (14)4922
MDL编号MFCD00866946

技术规格

AppearanceWhite to Almost white powder to crystal
Purity(HPLC)min. 98.0 area%
Purity(Nonaqueous Titration)min. 98.0 %

物性(参考值)

熔点294 ℃
最大吸收波长245(H2O/MeOH) nm
水溶性实际上不溶

安全信息

图形或危害标志
信号词危险
危险性说明H301 : 吞咽会中毒。
H315 : 造成皮肤刺激。
H319 : 造成严重眼刺激。
防范说明P501 : 将内装物/容器送到批准的废物处理厂处理。
P270 : 使用本产品时不要进食、饮水或吸烟。
P264 : 作业后彻底清洗皮肤。
P280 : 戴防护手套/戴防护眼罩/戴防护面具。
P302 + P352 : 如皮肤沾染：用水充分清洗。
P337 + P313 : 如仍觉眼刺激：求医/就诊。
P305 + P351 + P338 : 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。
P362+P364 : 脱掉沾污的衣服，清洗后方可重新使用。
P332 + P313 : 如发生皮肤刺激：求医/就诊。
P301 + P310 + P330 : 如误吞咽：立即呼叫急救中心/医生。漱口。
P405 : 存放处须加锁。

相关法规

RTECS#NJ5903450

运输信息

UN编号UN2811
类别6.1
包装类别 III
监管条件代码(*)
106898J&KImiquimod99%, 一种TLR7激动剂65元/10MG;   260元/50MG;   展开

基本信息

分子式C14H16N4
分子量240.31
熔点294
MDL编码MFCD00866946

产品描述

Imiquimod 是新型合成的药剂，具有免疫反应修饰活性。

靶点（IC50 & Targe）

TLR7

TLR8

安全信息

图形或危害标志
提示语Danger
危险说明H301
H315
H319
防范说明P264
P270
P280
P301+P310+P330
P302+P350
P305+P351+P338
P332+P313
P337+P313
P362
P405
P501
UN号码2811
危险分类6.1
包装等级III
WGK3
RTECSNJ5903450
TSCA否
R11003Alfa AesarImiquimod Standard solution100ppm838元/1ml;   展开

安全信息

危险等级
3

1338313USPImiquimodUnited States Pharmacopeia (USP) Reference Standard3231.47元/200 MG;   展开

产品说明

一般描述

本产品按照发布的药典交付和规定提供。为支持本产品而提供的所有信息，包括 SDS 和任何产品信息手册，均在发布药典授权下开发和发布。
欲了解更多信息和支持，请访问 药典发布网站 。

生化/生理作用

咪喹莫特是半胱天冬酶 3 激活剂，可直接诱导半胱天冬酶 3 裂解为活性半胱天冬酶 3。咪喹莫特在体内 诱导基底细胞癌凋亡 。其抗肿瘤活性与诱导细胞凋亡有关。咪喹莫特具有抗血管生成、抗炎、抗病毒活性。咪喹莫特还可作为免疫应答调节剂，诱导多种细胞因子和趋化因子的分泌。

分析说明

这些产品仅供测试和化验使用。它们不适用于人类或动物，也不能用于诊断、治疗或治愈任何类型的疾病。

其他说明

USP颁布的SDS请点击此处。
可能适用相应的销售限制。

基本信息

经验(实验)分子式C14H16N4
分子量240.30
MDL编号MFCD00866946
PubChem化学物质编号329750158
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameUSP
application(s)pharmaceutical (small molecule)
格式neat
SMILES stringCC(C)Cn1cnc2c(N)nc3ccccc3c12
InChI1S/C14H16N4/c1-9(2)7-18-8-16-12-13(18)10-5-3-4-6-11(10)17-14(12)15/h3-6,8-9H,7H2,1-2H3,(H2,15,17)
InChI keyDOUYETYNHWVLEO-UHFFFAOYSA-N
Gene Informationhuman ... TLR7(51284)

安全信息

象形图GHS06
警示用语：Danger
危险声明H300 - H315 - H319 - H335
预防措施声明P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338
危险分类Acute Tox. 2 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官Respiratory system
储存分类代码6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
401020Sigma-AldrichImiquimod-CAS 99011-02-6-CalbiochemAn imidazoquinoline compound that acts as a potent immunomodulator and displays anti-angiogenic, anti-viral and anti-inflammatory properties.3378.28元/250 MG;   展开

产品说明

一般描述

An imidazoquinoline compound that acts as a potent immunomodulator and displays anti-angiogenic, anti-viral and anti-inflammatory properties. Reported to bind to the cell surface receptor, TLR7 (toll-like receptor 7), and induce the secretion of several pro-inflammatory cytokines and chemokines both in vitro and in vivo.

包装

250 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Primary Target
TLR7 (toll-like receptor 7)
Product does not compete with ATP.
Reversible: no
Cell permeable: no

警告

Toxicity: Toxic (F)

制备说明

warming to 60°C is required for complete solubilization.

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Upon thawing, warming may be required to resolubilize precipitated product.

其他说明

Majewski, S., et al. 2005. Int. J. Dermatol.44, 14.
Gibson, S.J., et al. 2002. Cell. Immunol.218, 74.
Hemmi, H., et al. 2002. Nat. Immunol.3, 196.
Megyeri, K., et al. 1995. Mol. Cell. Biol.15, 2207.
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C14H16N4
分子量240.30
MDL编号MFCD00866946

产品性质

质量水平100
测定≥98% (HPLC)
形式solid
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
protect from light
颜色 white
溶解性DMSO: 3 mg/mL
运输ambient
储存温度2-8℃
InChI1S/C14H16N4/c1-9(2)7-18-8-16-12-13(18)10-5-3-4-6-11(10)17-14(12)15/h3-6,8-9H,7H2,1-2H3,(H2,15,17)
InChI keyDOUYETYNHWVLEO-UHFFFAOYSA-N

安全信息

象形图GHS06
警示用语：Danger
危险声明H301 - H315 - H319
预防措施声明P264 - P270 - P280 - P301 + P310 - P302 + P352 - P305 + P351 + P338
危险分类Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2
储存分类代码6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
386709Fluorochem4-Amino-1-isobutyl-1H-imidazo[4,5-c]quinoline97%814元/1g;   3476元/5g;   7304元/25g;   展开

基本信息

CAS Number99011-02-6
MDL NumberMFCD00866946
Melting Point292-294℃

安全信息

图形或危害标志
危险性说明 H300: Fatal if swallowed.
H301: Toxic if swallowed.
H315: Causes skin irritation.
H319: Causes serious eye irritation.
H335: May cause respiratory irritation.
防范说明 P233: Keep container tightly closed.
P260: Do not breathe .
P261: Avoid breathing
P264: Wash hands thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear .
P301 + P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P304: IF INHALED: .
P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P321: Specific treatment (see . on this label).
P330: Rinse mouth.
P332 + P313: If skin irritation occurs: Get medical advice/ attention.
P337 + P313: If eye irritation persists: Get medical advice/attention.
P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P362: Take off contaminated clothing and wash before reuse.
P403: Store in a well-ventilated place.
P403 + P233: Store in a well-ventilated place. Keep container tightly closed.
P405: Store locked up.
P501: Dispose of contents/container to local regulations.
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