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CAS: 99-05-8
分子式: C7H7NO2
分子量: 137.14
熔点: 172℃
中文名称: 
间氨基苯甲酸
3-氨基苯甲酸
M-氨基苯甲酸
英文名称: 
3-Aminobenzoic acid
3-amino-Benzoic acid
m-amino-benzoic aci
3-aminobenzoic
3-carboxyaniline
3-aminobenzoicacid
aniline-3-carboxylic acid
3-amino-benzoic aci
m-aminobenzoic acid
m-carboxyaniline
maba
Benzaminic acid
Benzoic acid,3-amino-
3-Aminobenzoesαure
3-Amino-benzoic acid
展开更多英文名
性质描述: 白色或淡黄色结晶。熔点174℃,相对密度1.5105(20/4℃)。易溶于丙酮,能溶于沸水、热醇、热氯仿和乙醚,微溶于冷水、冷醇和冷氯仿,不溶于苯及汽油。味甜。能升华。
生产方法: 1.间硝基苯甲酸催化加氢将间硝基苯甲酸溶于水中,加热至70℃以下,用10%液碱调节pH值,使pH值大于7。加入2%的活性炭,脱色20-30min,过滤。滤液以10%液碱调节pH8-8.5。向滤液中加入钯炭(即将2%氯化钯溶液缓缓加入水及活性炭的锅中,边加边搅拌,加完后再通氢气而得),加热至40-45℃,通氢至不再吸氢为止。滤去钯炭,得间氨基苯甲酸钠溶液。收率为95%。也可以用镍作催化剂,试验的结果,收率为99.8%;在1000ml烧杯中加入88%间硝基苯甲酸(按100%82.3g)、400ml水,用22%氢氧化钠调pH=6-7,待料液全溶后加入17g阮尼镍,在搅拌下把料液抽到摇摆式高压釜中,分别用氢气、氮气置换两次,再充压至3.92MPa,于压力2.94-3.92MPa、温度130-140℃下反应5h左右,氢压不下降为终点。经过滤、干燥而得成品。2.铁粉还原法在反应罐中加水、盐酸、氯化钠,升温到80℃。加入铁粉,95℃保温30min,分次投入间硝基苯甲酸,在100℃保温1h,冷却至80℃,用碳酸钠中和至pH9以上。于50℃时压滤,用水洗涤泥,得浅棕色还原液。用盐酸调节pH值,或用盐析的方法使间硝基苯甲酸析出,经过滤、干燥而得成品。收率90%。
用途: 医药和染料中间体。用于制造偶氮染料,医药乙碘苯酸和胆影酸,试剂。
推荐供应商
货号品牌产品名称规格包装、参考价格详情
767945MACKLIN间氨基苯甲酸溶液10mM in DMSO620元/1ml;   展开
储存:室温, 避光, 惰性气体
A800356MACKLIN间氨基苯甲酸98%41元/25g;   85元/100g;   341元/500g;   1448元/2.5kg;   展开
储存:RT
状态:白色到棕色粉末或晶体
A0268TCI3-Aminobenzoic Acid>99.0%(T)140元/25G;   595元/500G;   展开

基本信息

纯度/分析方法>99.0%(T)
分子式/分子量C7H7NO2 = 137.14
外观与形状(20℃)固体
应避免的情况
Reaxys-RN471603
PubChem物质ID87561923
SDBS (AIST Spectral DB)1153
Merck Index (14)421
MDL编号MFCD00007795

技术规格

AppearanceWhite to Light yellow to Light orange powder to crystal
Purity(HPLC)min. 98.0 area%
Purity(Neutralization titration)min. 99.0 %
Solubility in hot Methanolalmost transparency

物性(参考值)

熔点174 ℃
水溶性微溶
溶解性(微溶于)乙醇,乙醚

安全信息

图形或危害标志
信号词警告
危险性说明H315 : 造成皮肤刺激。
H319 : 造成严重眼刺激。
防范说明P264 : 作业后彻底清洗皮肤。
P280 : 戴防护手套/戴防护眼罩/戴防护面具。
P302 + P352 : 如皮肤沾染:用水充分清洗。
P337 + P313 : 如仍觉眼刺激:求医/就诊。
P305 + P351 + P338 : 如进入眼睛:用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出,取出隐形眼镜。继续冲洗。
P362+P364 : 脱掉沾污的衣服,清洗后方可重新使用。
P332 + P313 : 如发生皮肤刺激:求医/就诊。

相关法规

RTECS#DG1225000
446061J&K3-Aminobenzoic Acid98%72元/25G;   142元/100G;   566元/500G;   展开

基本信息

分子式C7H7NO2
分子量137.14
熔点178-180
闪点150
MDL编码MFCD00007795
Beilstein471603
Merck14,421
EINECS 编号202-724-4

安全信息

图形或危害标志
提示语Warning
危险说明H315
H319
H335
防范说明P261
P280
P302+P352
P305+P351+P338
WGK2
RTECSDG1225000
TSCA
984351J&K3-Aminobenzoic Acid99%92元/25G;   202元/100G;   展开

基本信息

分子式C7H7NO2
分子量137.14
熔点178-180
闪点150
MDL编码MFCD00007795
Beilstein471603
Merck14,421
EINECS 编号202-724-4

安全信息

图形或危害标志
提示语Warning
危险说明H315
H319
H335
防范说明P261
P280
P302+P352
P305+P351+P338
WGK2
RTECSDG1225000
TSCA
A19540Alfa Aesar3-Aminobenzoic Acid98%852元/100g;   2975元/500g;   12689元/2500g;   展开

应用
It finds its application as crystalline Intermediate for azo dyes, pharmaceuticals, and X-ray contrast media.

备注
Store away from oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.

基本信息

MDL
MFCD00007795

EINECS
202-724-4

分子式
C7H7NO2

分子量
137.14

熔点
172-179°

闪点
150°(302°F)

密度
1.51

灵敏度
Ambient temperatures.

形态
Powder

溶解性
Soluble in water at 20°C 5.9g/L. Solubility in hot methanol is almost transparent.

Beilstein
471603

Merck
14,421

GHS危害和防范说明

GHS符号

Hazard Statements
H315-H319-H335
Causes skin irritation.Causes serious eye irritation.May cause respiratory irritation.

Precautionary Statements
P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray.Wear protective gloves and eye/face protection.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.

安全信息

危险类别
36/37/38
Irritating to eyes, respiratory system and skin.

安全等级
26-37-60
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.This material and its container must be disposed of as hazardous waste

RTECS
DG1225000

TSCA

C15585Alfa Aesar3-Aminobenzoic Acid99+%556元/25g;   1011元/100g;   2900元/500g;   展开

基本信息

Ref#
15585

MDL
7795

分子式
C7 H7 N O2

分子量
137.14

闪点
150

形态
Powder

127671Sigma-Aldrich3-Aminobenzoic Acid98%160.47元/25 G;   214.79元/100 G;   908.35元/500 G;   展开

基本信息

线性分子式H2NC6H4CO2H
分子量137.14
Beilstein471603
EC 号202-724-4
MDL编号MFCD00007795
PubChem化学物质编号24847793
NACRESNA.22

产品性质

质量水平100
测定98%
reaction suitabilityreaction type: solution phase peptide synthesis
mp178-180 ℃ (lit.)
application(s)peptide synthesis
SMILES stringNc1cccc(c1)C(O)=O
InChI1S/C7H7NO2/c8-6-3-1-2-5(4-6)7(9)10/h1-4H,8H2,(H,9,10)
InChI keyXFDUHJPVQKIXHO-UHFFFAOYSA-N

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 2
闪点(F)302.0 °F
闪点(C)150 ℃
个人防护装备dust mask type N95 (US), Eyeshields, Gloves
PHR1743Supelco3-Aminobenzoic AcidPharmaceutical Secondary Standard; Certified Reference Material3096.84元/200 MG;   展开

产品说明

一般描述

3-Aminobenzoic acid, popularly known as Mesalazine Impurity E, is a related compound of anti-inflammatory agent Mesalazine. Mesalazine belongs to a group of drugs referred to as aminosalicylates and is generally used in the treatment of inflammatory bowel disease.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

应用

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
3-Aminobenzoic acid may be used as a pharmaceutical reference standard for the determination of the analyte in bulk drug and pharmaceutical formulations by high performance liquid chromatography.

分析说明

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

附注

To see an example of a Certificate of Analysis for this material enter LRAC4014 in the slot below. This is an example certificate only and may not be the lot that you receive.

基本信息

线性分子式H2NC6H4CO2H
分子量137.14
Beilstein471603
EC 号202-724-4
MDL编号MFCD00007795
PubChem化学物质编号329823588
NACRESNA.24

产品性质

质量水平300
等级certified reference material
pharmaceutical secondary standard
CofAcurrent certificate can be downloaded
包装pkg of 200 mg
technique(s)HPLC: suitable
gas chromatography (GC): suitable
mp178-180 ℃ (lit.)
application(s)pharmaceutical (small molecule)
格式neat
储存温度2-30℃
SMILES stringNc1cccc(c1)C(O)=O
InChI1S/C7H7NO2/c8-6-3-1-2-5(4-6)7(9)10/h1-4H,8H2,(H,9,10)
InChI keyXFDUHJPVQKIXHO-UHFFFAOYSA-N

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 2
闪点(F)302.0 °F
闪点(C)150 ℃
078487Fluorochem3-Aminobenzoic Acid97%220元/1g;   308元/25g;   506元/100g;   1188元/250g;   3674元/1kg;   展开

基本信息

CAS Number99-05-8
MDL NumberMFCD00007795
Boiling Point352.5 ℃ at 760 mmHg
Melting Point178-180℃

安全信息

图形或危害标志
危险性说明 H315: Causes skin irritation.
H319: Causes serious eye irritation.
H335: May cause respiratory irritation.
防范说明 P233: Keep container tightly closed.
P260: Do not breathe .
P261: Avoid breathing .
P264: Wash hands thoroughly after handling.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear .
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P304: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing..
P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P321: Specific treatment (see relevant procedures. on this label).
P332 + P313: If skin irritation occurs: Get medical advice/ attention.
P337 + P313: If eye irritation persists: Get medical advice/attention.
P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P362: Take off contaminated clothing and wash before reuse.
P403: Store in a well-ventilated place.
P403 + P233: Store in a well-ventilated place. Keep container tightly closed.
P405: Store locked up.
P501: Dispose of contents/container to in accordance with local regulation .
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