CAS 981-15-7; 2h-1,11c-(epoxymethano)phenanthro(10,1-bc)pyran-5,10(3h,6ah)-dione, 1,3a,4,7,7a

CAS:

981-15-7

分子式:

C₂₀H₂₄O₇

分子量:

376.4

英文名称:

2h-1,11c-(epoxymethano)phenanthro(10,1-bc)pyran-5,10(3h,6ah)-dione, 1,3a,4,7,7a

,11,11a,11b- octahydro-8,11a-beta-dimethyl-3-methylene-1-alpha,2-beta,11-beta-t

rihydrox y-

ailanthone

ailantone

picrasa-3,13(21)-diene-2,16-dione, 11,20-epoxy-1,11,12-trihydroxy-, (1-beta,1

12-alpha)-1-bet

1-bc)pyran-5,10(3h,6ah)-dione,1,3a,4,7,7a,11,11a,11b-octahydro-8,11a2h-11c-(epoxymethano)phenanthro(10

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

详情

A861466

MACKLIN

臭椿酮

98%（HPLC）

1399元/10mg; 4019元/50mg;

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储存：2-8ºC
状态：白色到米黄色粉末

1415397

J&K

Ailanthone

98%, 来源于臭椿

3300元/20MG;

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基本信息

分子式	C₂₀H₂₄O₇
分子量	376.4

SML2143

Sigma-Aldrich

Ailanthone

≥98% (HPLC)

1619.17元/5 MG; 6511.37元/25 MG;

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产品说明

生化/生理作用

Ailanthone, natural compound isolated from Ailanthus altissima (Simaroubaceae), is a potent inhibitor of androgen receptor (AR) that blocks activities of full-length AR and AR splice variants. It overcomes MDV3100 (Enzalutamide)-resistance in castration-resistant prostate cancer cell lines. Ailanthone disrupts the interaction between AR and the chaperones HSP90, HSP70, and HSP40, which leads to AR ubiquitination and degradation.

基本信息

经验(实验)分子式	C₂₀H₂₄O₇
分子量	376.40
EC 号	683-145-8
NACRES	NA.77

产品性质

测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 2 mg/mL, clear
储存温度	−20℃
SMILES string	O[C@@H]1C([C@]([C@@]2([C@]3([H])[C@@]1(O)OC2)[C@@](O4)([H])C[C@@]([C@]3(C)[C@@H]5O)([H])C(C)=CC5=O)([H])CC4=O)=C
InChI	1S/C20H24O7/c1-8-4-12(21)16(24)18(3)10(8)5-13-19-7-26-20(25,17(18)19)15(23)9(2)11(19)6-14(22)27-13/h4,10-11,13,15-17,23-25H,2,5-7H2,1,3H3/t10-,11-,13+,15+,16+,17+,18+,19+,20-/m0/s1
InChI key	WBBVXGHSWZIJST-RLQYZCPESA-N

安全信息

象形图
警示用语：	Danger
危险声明	H300
预防措施声明	P301 + P330 + P331 + P310
危险分类	Acute Tox. 2 Oral
储存分类代码	6.1B - Non-combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable