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CAS: 98-79-3
分子式: C5H7NO3
分子量: 129.11
熔点: 152-162℃
中文名称: 
L-2-吡咯烷酮-5-羧酸
L-焦性胶氨酸
5-氧代-L-脯氨酸
L-焦谷氨酸
英文名称: 
l-pyroglutamic
l-pyroglutamicacid
L-Pyronglutamic acid
L-Glutiminoic acid
Glutamic acid lactone
L-5-Oxo-2-pyrrolidine carboxylic acid
L-Pyroglutamic acid
5-oxo-L-Proline
(-)-2-pyrrolidone-5-carboxylic acid
(-)-pyroglutamic acid
(5S)-2-oxopyrrolidine-5-carboxylic acid
(S)-(-)-2-pyrrolidone-5-carboxylic acid
(S)-2-pyrrolidone-5-carboxylic acid
(S)-5-oxo-2-pyrrolidinecarboxylic acid
(S)-pyroglutamic acid
2-benzothiazolesulfenic acid morpholide
2-l-pyrrolidone-5-carboxylic acid
2-oxopyrrolidine-5-carboxylic acid
2-pyrrolidinone-5-carboxylic acid
2-pyrrolidone-5-carboxylate
5-carboxy-2-pyrrolidinone
5-oxo-2-pyrrolidinecarboxylic acid
5-oxo-l-proline
5-oxoproline
5-pyrrolidinone-2-carboxylic acid
ajidew a-100
glutimic acid
glutiminic acid
l-2-pyrrolidone-5-carboxylic acid
l-5-carboxy-2-pyrrolidinone
l-5-oxo-2-pyrrolidinecarboxylic acid
l-5-oxoproline
l-glutamic acid gamma-lactam
l-glutimic acid
l-glutiminic acid
5-oxo-l-prolin
l-pyrrolidinonecarboxylic acid
l-pyrrolidonecarboxylic acid
oxoproline
pidolic acid
5-oxo-prolin
pyroglutamic acid
pyrrolidinonecarboxylic acid
pyrrolidone-5-carboxylic acid
pyrrolidonecarboxylic acid
展开更多英文名
性质描述: 无色结晶。熔点162-163℃,溶于水、醇、丙酮和冰醋酸,微溶于乙酸乙酯,不溶于醚。
生产方法: 有半合成法、酶转化法和全合成法。目前工业生产的主要方法是以谷氨酸为原料的半合成法。将42%谷氨酸水溶液在140℃加热3h,得到L-焦谷氨酸为主要成分的反应液。经减压浓缩、结晶、洗涤、干燥,即得L-焦谷氨酸,转化率为94%。
用途: 用作有机合成中间体,食品添加剂等。
推荐供应商
货号品牌产品名称规格包装、参考价格详情
H815790MACKLINL-焦谷氨酸99%29元/25g;   44元/100g;   99元/500g;   350元/2.5kg;   展开
储存:室温
状态:白色到灰白色粉末或晶体
H815789MACKLINL-焦谷氨酸97%30元/100g;   58元/500g;   展开
储存:室温
状态:白色到几乎白色粉末到晶体
L767898MACKLINL-焦谷氨酸10mM in DMSO185元/1ml;   展开
储存:-20°C
P0573TCIL-Pyroglutamic Acid>97.0%(T)215元/25G;   605元/100G;   1090元/500G;   展开

基本信息

纯度/分析方法>97.0%(T)
分子式/分子量C5H7NO3 = 129.12
外观与形状(20℃)固体
储存在惰性气体下存放于惰性气体之中
应避免的情况湿气 (吸湿)
Reaxys-RN82132
PubChem物质ID87574744
SDBS (AIST Spectral DB)5383
Merck Index (14)8001
MDL编号MFCD00005272

技术规格

AppearanceWhite to Almost white powder to crystal
Optical purity(LC)min. 95.0 ee%
Purity(Neutralization titration)min. 97.0 %
Melting point157.0 to 164.0 ℃

物性(参考值)

熔点160 ℃
比旋光度 [α]D-10° (C=5,H2O)
水溶性可溶
溶解性(可溶于)醇,丙酮

安全信息

图形或危害标志
信号词警告
危险性说明H315 : 造成皮肤刺激。
H319 : 造成严重眼刺激。
防范说明P264 : 作业后彻底清洗皮肤。
P280 : 戴防护手套/戴防护眼罩/戴防护面具。
P302 + P352 : 如皮肤沾染:用水充分清洗。
P337 + P313 : 如仍觉眼刺激:求医/就诊。
P305 + P351 + P338 : 如进入眼睛:用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出,取出隐形眼镜。继续冲洗。
P362+P364 : 脱掉沾污的衣服,清洗后方可重新使用。
P332 + P313 : 如发生皮肤刺激:求医/就诊。

相关法规

RTECS#TW3710000
229913J&KL-Pyroglutamic Acid99%60元/25G;   95元/100G;   展开

基本信息

分子式C5H7NO3
分子量129.11
熔点160-163
比旋光度([α]20D)-12 to -8 (C=5, H2O)
MDL编码MFCD00005272
Beilstein82132
Merck14,8001
EINECS 编号202-700-3

安全信息

图形或危害标志
提示语Warning
危险说明H315
H319
H335
防范说明P261
P305+P351+P338
WGK3
RTECSTW3710000
TSCA
L11711Alfa Aesar(S)-(-)-2-Pyrrolidinone-5-carboxylic acid98+%267元/25g;   772元/100g;   3155元/500g;   展开

应用
(S)-(-)-2-Pyrrolidinone-5-carboxylic acid is used as a building block for pharmaceuticals and asymmetric synthesis. It Is also used as a resolving agent for chiral bases and in an efficient synthesis of quinolizidine and indolizidine alkaloids.

备注
Keep container tightly sealed. Store in cool, dry conditions in well sealed containers. Incompatible with oxidizing agents.

基本信息

MDL
MFCD00005272

EINECS
202-700-3

分子式
C5H7NO3

分子量
129.12

熔点
158-162°

灵敏度
Ambient temperatures.

形态
Powder

溶解性
Soluble in water (10-15% at 20°C), alcohol, acetone, dimethyl sufoxide and methanol.

Beilstein
82132

Merck
14,8001

GHS危害和防范说明

GHS符号

Hazard Statements
H315-H319-H335
Causes skin irritation.Causes serious eye irritation.May cause respiratory irritation.

Precautionary Statements
P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray.Wear protective gloves and eye/face protection.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.

安全信息

危险类别
36/37/38
Irritating to eyes, respiratory system and skin.

安全等级
26-37-60
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.This material and its container must be disposed of as hazardous waste

RTECS
TW3710000

TSCA

C13212Alfa Aesar(S)-(-)-2-Pyrrolidone-5-carboxylic acid98%591元/25g;   1203元/100g;   5264元/500g;   展开

基本信息

Ref#
13212

MDL
5272

分子式
C5 H7 N O3

分子量
129.12

Y0000123Pidolic acidEuropean Pharmacopoeia (EP) Reference Standard1572.27元/ ;   展开

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

包装

Unit quantity: 125 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

注意

Please find SDS provided by EDQM here..

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式C5H7NO3
分子量129.11
Beilstein82132
MDL编号MFCD00005272
PubChem化学物质编号329830856
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameEDQM
mp160-163 ℃ (lit.)
application(s)pharmaceutical (small molecule)
格式neat
储存温度2-8℃
SMILES stringOC(=O)[C@@H]1CCC(=O)N1
InChI1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/t3-/m0/s1
InChI keyODHCTXKNWHHXJC-VKHMYHEASA-N

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
1589029USPPyroglutamic acidUnited States Pharmacopeia (USP) Reference Standard5490.17元/30 MG;   展开

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including MSDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

分析说明

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

其他说明

USP issued SDS can be found here.
Sales restrictions may apply.

基本信息

经验(实验)分子式C5H7NO3
分子量129.11
Beilstein82132
MDL编号MFCD00005272
PubChem化学物质编号329751000
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameUSP
mp160-163 ℃ (lit.)
格式neat
储存温度2-8℃
SMILES stringOC(=O)[C@@H]1CCC(=O)N1
InChI1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/t3-/m0/s1
InChI keyODHCTXKNWHHXJC-VKHMYHEASA-N

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
83160Sigma-AldrichL-Pyroglutamic acid≥99.0% (T)310.5元/25 G;   687.29元/100 G;   3160.76元/500 G;   展开

产品说明

应用

使用L-焦谷氨酸合成:

  • 非蛋白氨基酸,例如(3S,4R)-3,4-二甲基-L-焦谷氨酸和(3S,4R)-3,4-二甲基-L-谷氨酰胺。
  • 手性N-杂环卡宾(NHC)作为催化剂,用于烷基芳基烯酮的不对称的二聚作用以产生相应的α-四价 β-alkylidenyl-β-内酯。

此外,还用于(−)-百部酰胺和青箱C的全合成。

包装

25, 100, 500 g in poly bottle

基本信息

经验(实验)分子式C5H7NO3
分子量129.11
Beilstein82132
EC 号202-700-3
MDL编号MFCD00005272
PubChem化学物质编号57652948
NACRESNA.22

产品性质

质量水平200
测定≥99.0% (T)
旋光性[α]20/D −10.5±1°, c = 5% in H2O
光学纯度enantiomeric ratio: ≥99:1 (GC)
reaction suitabilityreaction type: solution phase peptide synthesis
灼烧残渣≤0.05%
mp155-162 ℃
160-163 ℃ (lit.)
application(s)peptide synthesis
SMILES stringOC(=O)[C@@H]1CCC(=O)N1
InChI1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/t3-/m0/s1
InChI keyODHCTXKNWHHXJC-VKHMYHEASA-N

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
个人防护装备dust mask type N95 (US), Eyeshields, Gloves
P5960Sigma-AldrichL-Pyroglutamic acidBioXtra853.41元/25 G;   展开

基本信息

经验(实验)分子式C5H7NO3
分子量129.11
Beilstein82132
EC 号202-700-3
MDL编号MFCD00005272
PubChem化学物质编号24898722
NACRESNA.26

产品性质

质量水平200
产品线BioXtra
测定≥97% (titration)
形式powder
technique(s)cell culture | plant: suitable
杂质≤0.0005% Phosphorus (P)
灼烧残渣≤0.1%
颜色 white
mp160-163 ℃ (lit.)
溶解性H2O: 1 M, clear, colorless
痕量阴离子chloride (Cl-): ≤0.05%
sulfate (SO42-): ≤0.05%
痕量阳离子Al: ≤0.0005%
Ca: ≤0.0005%
Cu: ≤0.0005%
Fe: ≤0.0005%
K: ≤0.005%
Mg: ≤0.0005%
NH4+: ≤0.05%
Na: ≤0.005%
Pb: ≤0.001%
Zn: ≤0.0005%
SMILES stringOC(=O)[C@@H]1CCC(=O)N1
InChI1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/t3-/m0/s1
InChI keyODHCTXKNWHHXJC-VKHMYHEASA-N

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
个人防护装备dust mask type N95 (US), Eyeshields, Gloves
PHR2817SupelcoPyroglutamic acidPharmaceutical Secondary Standard; Certified Reference Material2107.71元/100 MG;   展开

产品说明

一般描述

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

分析说明

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

附注

To see an example of a Certificate of Analysis for this material enter LRAC6444 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

基本信息

经验(实验)分子式C5H7NO3
分子量129.11
Beilstein82132
MDL编号MFCD00005272

产品性质

等级certified reference material
pharmaceutical secondary standard
形式solid
包装pkg of 100 mg
mp160-163 ℃ (lit.)
药典可追溯性traceable to PhEur Y0000123
traceable to USP 1589029
储存温度2-8℃
SMILES stringOC(=O)[C@@H]1CCC(=O)N1
InChI1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/t3-/m0/s1
InChI keyODHCTXKNWHHXJC-VKHMYHEASA-N

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
M03204FluorochemH-Pyr-OH>99%220元/25g;   528元/250g;   880元/500g;   1452元/1kg;   展开

基本信息

CAS Number98-79-3
MDL NumberMFCD00005272
Melting Point161.9℃
Density0.696

安全信息

图形或危害标志
危险性说明 H315: Causes skin irritation.
H318: Causes serious eye damage.
H335: May cause respiratory irritation.
防范说明 P233: Keep container tightly closed.
P260: Do not breathe .
P261: Avoid breathing .
P264: Wash hands thoroughly after handling.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear .
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P304: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing..
P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P310: Immediately call a POISON CENTER or doctor/physician.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P321: Specific treatment (see relevant procedures. on this label).
P332 + P313: If skin irritation occurs: Get medical advice/ attention.
P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P362: Take off contaminated clothing and wash before reuse.
P403: Store in a well-ventilated place.
P403 + P233: Store in a well-ventilated place. Keep container tightly closed.
P405: Store locked up.
P501: Dispose of contents/container to in accordance with local regulation .
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